Affiliation:
1. Department of Medicine, Santa Clara Valley Medical Center, San Jose, California.
Abstract
Concentrations of oral azoles in serum were compared in a single-dose pharmacologic study in mice. When hydroxypropyl-beta-cyclodextrin was used as a carrier and compared with a standard carrier, polyethylene glycol, drug concentrations determined by bioassay showed that the peak concentration and area under the concentration-time curve were greatly enhanced for itraconazole and saperconazole; moderately enhanced for ketoconazole; but negligibly affected for fluconazole, miconazole, and SCH 42427.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference10 articles.
1. Increased gastric pH and the bioavailability of fluconazole and ketoconazole;Blum R. A.;Ann. Intern. Med.,1991
2. Disposition of ketoconazole, an oral antifungal, in humans;Brass C.;Antimicrob. Agents Chemother.,1982
3. Treatment of invasive aspergillosis with itraconazole;Denning D. W.;Am. J. Med.,1989
4. Molecular modifications of imidazole compounds: studies of activity and synergy in vitro and of pharmacology and therapy of blastomycosis in a mouse model;Harvey R. P.;Rev. Infect. Dis.,1980
5. Treatment of paracoccidioidomycosis with itraconazole in a murine model;McEwen J. G.;J. Trop. Med. Hyg.,1985
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