Experimental model of congenital syphilis

Author:

Kajdacsy-Balla A1,Howeedy A1,Bagasra O1

Affiliation:

1. Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City 73190.

Abstract

Female LSH hamsters infected with Treponema pallidum subsp, endemicum before pregnancy or during early pregnancy transmit a form of syphilis to the fetus that is similar to human congenital syphilis. The offspring develops rhinitis, skin rash, failure to thrive, and hepatosplenomegaly. T. pallidum is detectable in their livers, spleens, and nasal secretions. Immunoglobulin M antibodies are detected in the serum.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference10 articles.

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3. Syphilis in the Syrian hamsters: a model of human venereal and congenital syphilis;Balla A. K.;Am. J. Pathol.,1987

4. Coe J. E. (Rocky Mountain Laboratories National Institute of Allergy and Infectious Diseases Hamilton Mont.). Personal communication.

5. Congenital syphilis;Crissey J. T.;Clin. Dermatol.,1984

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