Analysis of the Oxidative Stress Regulon Identifies soxS as a Genetic Target for Resistance Reversal in Multidrug-Resistant Klebsiella pneumoniae-Reference-Cited by-同舟云学术

Analysis of the Oxidative Stress Regulon Identifies soxS as a Genetic Target for Resistance Reversal in Multidrug-Resistant Klebsiella pneumoniae

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Anes João¹^ORCID,Dever Katherine¹^ORCID,Eshwar Athmanya²^ORCID,Nguyen Scott¹^ORCID,Cao Yu¹^ORCID,Sivasankaran Sathesh K.³^ORCID,Sakalauskaitė Sandra⁴^ORCID,Lehner Angelika²^ORCID,Devineau Stéphanie⁵^ORCID,Daugelavičius Rimantas⁴^ORCID,Stephan Roger²^ORCID,Fanning Séamus¹⁶^ORCID,Srikumar Shabarinath¹⁷^ORCID

Affiliation:

1. UCD-Centre for Food Safety, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland

2. Institute for Food Safety and Hygiene, University of Zurich, Zurich, Switzerland

3. Genome Informatics Facility, Iowa State University, Ames, Iowa, USA

4. Department of Biochemistry, Faculty of Natural Sciences, Vytautas Magnus University, Kaunas, Lithuania

5. Université de Paris, BFA, UMR 8251, CNRS, Paris, France

6. Institute for Global Food Security, Queen’s University Belfast, Belfast, United Kingdom

7. Department of Food, Nutrition, and Health, College of Food and Agriculture, United Arab Emirates University, Al Ain, UAE

Abstract

Antimicrobial resistance is a global health challenge. Few new antibiotics have been developed for use over the years, and preserving the efficacy of existing compounds is an important step to protect public health. This paper describes a study that examines the effects of exogenously induced oxidative stress on K. pneumoniae and uncovers a target that could be useful to harness as a strategy to mitigate resistance.

Funder

Department of Agriculture, Food and the Marine, Ireland

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00867-21

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