Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus-Reference-Cited by-同舟云学术

Functional Genomic and Biochemical Analysis Reveals Pleiotropic Effect of Congo Red on Aspergillus fumigatus

Published:2021-05-18 Issue: Volume: Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Liu Zhonghua¹²,Raj Shriya¹,van Rhijn Norman³,Fraczek Marcin³,Michel Jean-Philippe⁴,Sismeiro Odile⁵,Legendre Rachel⁵²,Varet Hugo⁵²^ORCID,Fontaine Thierry¹,Bromley Michael³,Latgé Jean-Paul¹

Affiliation:

1. Unité des Aspergillus, Institut Pasteur, Paris, France

2. Bioinformatics and Biostatistics Hub, Department of Computational Biology, Institut Pasteur, Paris, France

3. Manchester Fungal Infection Group, The University of Manchester, Manchester, United Kingdom

4. Institut Galien Paris Sud, UMR CNRS 8612, Châtenay-Malabry, France

5. Transcriptome and Epigenome Platform, Biomics, C2RT, Institut Pasteur, Paris, France

Abstract

The compound Congo red (CR) has been historically used for coloring treatment and histological examination as well to inhibit the growth of yeast and filamentous fungi. It has been thought that CR binds to β-1,3-glucans in the fungal cell wall, disrupting the organization of the cell wall structure.

Funder

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

Wellcome

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00863-21

Reference89 articles.

1. Congo Red and amyloids: history and relationship