A Reverse Genetic Approach for Studying sRNAs in Chlamydia trachomatis

Author:

Wang Kevin1,Sheehan Lauren1,Ramirez Cuper2,Densi Asha1,Rizvi Syed1,Ekka Roseleen2,Sütterlin Christine2ORCID,Tan Ming13ORCID

Affiliation:

1. Department of Microbiology and Molecular Genetics, University of California, Irvine, California, USA

2. Department of Developmental and Cell Biology, University of California, Irvine, California, USA

3. Department of Medicine, University of California, Irvine, California, USA

Abstract

Small RNAs (sRNAs) are a class of regulatory RNAs that play important roles in bacterial physiology and pathogenesis. In the intracellular bacterium Chlamydia , however, sRNAs are poorly understood, and functional studies have been limited to a heterologous system.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference49 articles.

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2. Annual statistics from the National Notifiable Diseases Surveillance System (NNDSS). https://wonder.cdc.gov/nndss/nndss_annual_tables_menu.asp.

3. Batteiger BE, Tan M. 2019. Chlamydia trachomatis (trachoma and urogenital infections), p 2301–2319. In Bennett JE, Dolin R, Blaser MJ (ed), Mandell, Douglas, and Bennett’s principles and practice of infectious diseases, 9th ed Elsevier Inc., Philadelphia, PA.

4. Interaction of chlamydiae and host cells in vitro

5. Replication-dependent size reduction precedes differentiation in Chlamydia trachomatis

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