A Primed Subpopulation of Bacteria Enables Rapid Expression of the Type 3 Secretion System in Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

A Primed Subpopulation of Bacteria Enables Rapid Expression of the Type 3 Secretion System in Pseudomonas aeruginosa

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Lin Christina K.¹,Lee Daniel S. W.²,McKeithen-Mead Saria³,Emonet Thierry⁴⁵,Kazmierczak Barbara³⁶^ORCID

Affiliation:

1. Medical Scientist Training Program, Yale University, New Haven, Connecticut, USA

2. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut, USA

3. Department of Medicine (Infectious Diseases), Yale University, New Haven, Connecticut, USA

4. Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut, USA

5. Department of Physics, Yale University, New Haven, Connecticut, USA

6. Department of Microbial Pathogenesis, Yale University, New Haven, Connecticut, USA

Abstract

The expression of specific virulence traits is strongly associated with Pseudomonas aeruginosa ’s success in establishing acute infections but is thought to carry a cost for bacteria. Producing multiprotein secretion systems or motility organelles is metabolically expensive and can target a cell for recognition by innate immune system receptors that recognize structural components of the type 3 secretion system (T3SS) or flagellum.

Funder

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00831-21

Reference60 articles.

1. Microbial cell individuality and the underlying sources of heterogeneity

2. Bistability in bacteria

3. Bacterial Persistence as a Phenotypic Switch

4. Social evolution theory for microorganisms

5. Self-destructive cooperation mediated by phenotypic noise

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Microfluidic approaches in microbial ecology;Lab on a Chip;2024

2. Nutrient Gradients Mediate Complex Colony-Level Antibiotic Responses in Structured Microbial Populations;Frontiers in Microbiology;2022-04-27

3. Impact of horizontal gene transfer on emergence and stability of cooperative virulence in Salmonella Typhimurium;Nature Communications;2022-04-11

4. Nutrient gradients mediate creation of highly resistant layers in structured microbial populations during antibiotic exposures;2022-02-03