An Egg-Derived Sulfated N -Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines-Reference-Cited by-同舟云学术

An Egg-Derived Sulfated N -Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines

Published:2021-06-29 Issue:3 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Guthmiller Jenna J.¹,Utset Henry A.¹,Henry Carole¹,Li Lei¹,Zheng Nai-Ying¹,Sun Weina²,Costa Vieira Marcos³,Zost Seth⁴,Huang Min¹,Hensley Scott E.⁴^ORCID,Cobey Sarah³,Palese Peter²,Wilson Patrick C.¹^ORCID

Affiliation:

1. Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA

2. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

3. Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, USA

4. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA

Abstract

Influenza viruses grown in eggs for the purposes of vaccine generation often acquire mutations during egg adaptation or possess different glycosylation patterns than viruses circulating among humans. Here, we report that seasonal influenza virus vaccines possess an egg-derived glycan that is an antigenic decoy, with egg-binding MAbs reacting with a sulfated N -acetyllactosamine (LacNAc).

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.00838-21

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