Transcytosis of IgA Attenuates Salmonella Invasion in Human Enteroids and Intestinal Organoids-Reference-Cited by-同舟云学术

Transcytosis of IgA Attenuates Salmonella Invasion in Human Enteroids and Intestinal Organoids

Published:2022-06-16 Issue:6 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Costello Cait M.¹,Willsey Graham G.²,Richards Angelene F.²,Kim Jaeyoon¹,Pizzuto Matteo S.³,Jaconi Stefano³,Benigni Fabio³,Corti Davide³,Mantis Nicholas J.²^ORCID,March John C.¹^ORCID

Affiliation:

1. Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York, USA

2. Division of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA

3. Humabs BioMed SA a Subsidiary of Vir Biotechnology Inc., Bellinzona, Switzerland

Abstract

Secretory IgA (SIgA) is the most abundant antibody type in intestinal secretions where it contributes to safeguarding the epithelium from invasive pathogens like the Gram-negative bacterium, Salmonella enterica serovar Typhimurium (STm). For example, we recently reported that passive oral administration of the recombinant monoclonal SIgA antibody, Sal4, to mice promotes STm agglutination in the intestinal lumen and restricts bacterial invasion of Peyer’s patch tissues.

Funder

Bill and Melinda Gates Foundation

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00041-22

Reference71 articles.

1. An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation

2. Entry Route of Salmonella typhimurium Directs the Type of Induced Immune Response