Contribution of Noncanonical Antigens to Virulence and Adaptive Immunity in Human Infection with Enterotoxigenic E. coli-Reference-Cited by-同舟云学术

Contribution of Noncanonical Antigens to Virulence and Adaptive Immunity in Human Infection with Enterotoxigenic E. coli

Published:2021-04-16 Issue:5 Volume:89 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kuhlmann F. M.¹^ORCID,Laine R. O.¹,Afrin S.¹,Nakajima R.²³^ORCID,Akhtar M.⁴,Vickers T.¹,Parker K.¹,Nizam N. N.⁴,Grigura V.¹,Goss C. W.⁵,Felgner P. L.²,Rasko D. A.⁶⁷^ORCID,Qadri F.⁴^ORCID,Fleckenstein J. M.¹⁸^ORCID

Affiliation:

1. Department of Internal Medicine, Division of Infectious Diseases, Washington University, St. Louis, Missouri, USA

2. Vaccine R&D Center, University of California, Irvine, Irvine, California, USA

3. Department of Physiology and Biophysics, University of California, Irvine, Irvine, California, USA

4. Infectious Diseases Division, International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), Dhaka, Bangladesh

5. Division of Biostatistics, Washington University, St. Louis, Missouri, USA

6. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA

7. Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA

8. Medicine Service, Veterans Affairs Medical Center, St. Louis, Missouri, USA

Abstract

Enterotoxigenic Escherichia coli (ETEC) contributes significantly to the substantial burden of infectious diarrhea among children living in low- and middle-income countries. In the absence of a vaccine for ETEC, children succumb to acute dehydration as well as nondiarrheal sequelae related to these infections, including malnutrition.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00041-21

Reference60 articles.

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2. Burden of enterotoxigenic Escherichia coli and shigella non-fatal diarrhoeal infections in 79 low-income and lower middle-income countries: a modelling analysis