Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes-Reference-Cited by-同舟云学术

Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes

Published:2020-06-22 Issue:7 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Holly Mayumi K.¹^ORCID,Han Xiao²,Zhao Edward J.³,Crowley Shauna M.²,Allaire Joannie M.²,Knodler Leigh A.⁴^ORCID,Vallance Bruce A.²^ORCID,Smith Jason G.¹^ORCID

Affiliation:

1. Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA

2. Division of Gastroenterology, Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada

3. Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington, USA

4. Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA

Abstract

Recent studies have determined that inflammasome signaling plays an important role in driving intestinal epithelial cell (IEC) responses to bacterial infections, such as Salmonella enterica serovar Typhimurium. There are two primary inflammasome pathways, canonical (involving caspase-1) and noncanonical (involving caspase-4 and -5 in humans and caspase-11 in mice). Prior studies identified the canonical inflammasome as the major pathway leading to interleukin-18 (IL-18) release and restriction of S .

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

HHS | NIH | NIH Office of the Director

Gouvernement du Canada | Canadian Institutes of Health Research

Crohn's and Colitis Canada

University of Washington

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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