Host Genome-Wide Association Study of Infant Susceptibility to Shigella -Associated Diarrhea

Author:

Duchen Dylan1ORCID,Haque Rashidul2,Chen Laura1,Wojcik Genevieve1,Korpe Poonum1,Nayak Uma3,Mentzer Alexander J.4,Kirkpatrick Beth5,Petri William A.6ORCID,Duggal Priya1

Affiliation:

1. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

2. International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

3. Department of Public Health Sciences, Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, Virginia, USA

4. Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

5. University of Vermont College of Medicine, Vaccine Testing Center, Burlington, Vermont, USA

6. Department of Medicine, Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA

Abstract

Shigella is a leading cause of moderate-to-severe diarrhea globally and the causative agent of shigellosis and bacillary dysentery. Associated with 80 to 165 million cases of diarrhea and >13% of diarrheal deaths, in many regions, Shigella exposure is ubiquitous while infection is heterogenous.

Funder

Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases Discovery Program

Bill and Melinda Gates Foundation

Burroughs Wellcome Fund

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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