Affiliation:
1. Department of Microbiology, West Virginia University Medical Center, Morgantown, West Virginia
2. Department of Botany and Microbiology, Oklahoma University, Norman, Oklahoma
Abstract
Seven commercial and five experimental organic fungicides were tested against
Histoplasma capsulatum, Cryptococcus neoformans, Allescheria boydii
, and
Sporotrichum schenckii
in a series of laboratory studies. Preliminary agar dilution plate tests indicated that Lanstan, DAC 649, DAC 469, DAC 2787, He 3944, maneb, and nabam, in order of decreasing activity, inhibited all test fungi. Terraclor, Dexon, and He 13274 were active only in high concentration. The best fungicidal properties were exhibited by Lanstan, Vapam, and DAC 649; maneb, nabam, DAC 469, and DAC 2787 were fungicidal but to a lesser degree than the former compounds. In subsequent tests against
H. capsulatum
and
C. neoformans
in artificially infested soil or by use of the buried plug technique, Lanstan, Vapam, and DAC 649 showed good activity and merit further study.
Publisher
American Society for Microbiology
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
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