Affiliation:
1. Clinical Gene Therapy Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-1851
Abstract
SUMMARY
Gene therapy is being investigated as an alternative treatment for a wide range of infectious diseases that are not amenable to standard clinical management. Approaches to gene therapy for infectious diseases can be divided into three broad categories: (i) gene therapies based on nucleic acid moieties, including antisense DNA or RNA, RNA decoys, and catalytic RNA moieties (ribozymes); (ii) protein approaches such as transdominant negative proteins and single-chain antibodies; and (iii) immunotherapeutic approaches involving genetic vaccines or pathogen-specific lymphocytes. It is further possible that combinations of the aforementioned approaches will be used simultaneously to inhibit multiple stages of the life cycle of the infectious agent.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Microbiology (medical),Public Health, Environmental and Occupational Health,General Immunology and Microbiology,Epidemiology
Reference166 articles.
1. GEM 91—an antisense oligonucleotide phosphorothioate as a therapeutic agent for AIDS.;Agrawal S.;Antisense Res. Dev.,1992
2. Inhibition of HIV-1 by a double-transdominant fusion gene.;Aguilar-Cordova E.;Gene Ther.,1995
3. Specific inhibition of hepatitis C viral gene expression by antisense phosphorothioate oligodeoxynucleotides.;Alt M.;Hepatology,1995
4. Human gene therapy.;Anderson W. F.;Science,1992
5. Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region
Cited by
93 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献