Staphylococcal IgM Enzyme-Linked Immunosorbent Assay for Diagnosis of Periprosthetic Joint Infections-Reference-Cited by-同舟云学术

Staphylococcal IgM Enzyme-Linked Immunosorbent Assay for Diagnosis of Periprosthetic Joint Infections

Published:2011-01 Issue:1 Volume:49 Page:423-425
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Artini Marco¹,Romanò Carlo²,Manzoli Lamberto³,Scoarughi Gian Luca¹,Papa Rosanna¹,Meani Enzo⁴,Drago Lorenzo²,Selan Laura¹

Affiliation:

1. Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy

2. IRCCS Galeazzi Orthopaedic Institute, Milan, Italy

3. Section of Epidemiology and Public Health, G. d'Annunzio University, Chieti, Italy

4. G. Pini Orthopaedic Institute, Milan, Italy

Abstract

ABSTRACT Delayed orthopedic joint prosthesis infections (DOJP-Is) due to staphylococci frequently result in prosthetic revision. Specific and noninvasive diagnostic tests are unavailable, and DOJP-Is are commonly diagnosed at advanced stages of disease. An enzyme-linked immunosorbent assay (ELISA) was developed to detect serum antibodies against staphylococcal slime polysaccharide antigens. Using a cutoff of 0.35 ELISA units, the test showed a specificity of 95.1% (95% confidence interval [CI], 85.4 to 98.7%) and a sensitivity of 89.7% (71.5 to 97.3%) on a sample of 90 individuals.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01836-10

Reference11 articles.

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