Contribution of Neuraminidase to the Efficacy of Seasonal Split Influenza Vaccines in the Ferret Model-Reference-Cited by-同舟云学术

Contribution of Neuraminidase to the Efficacy of Seasonal Split Influenza Vaccines in the Ferret Model

Published:2022-03-23 Issue:6 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Rosu Miruna E.¹,Kok Adinda¹,Bestebroer Theo M.¹,de Meulder Dennis¹,Verveer Elwin P.¹,Pronk Mark R.¹,Dekker Lennard J. M.²,Luider Theo M.²,Richard Mathilde¹^ORCID,van den Brand Judith M. A.³,Fouchier Ron A. M.¹,Herfst Sander¹^ORCID

Affiliation:

1. Department of Viroscience, Erasmus Medical Centre, Rotterdam, the Netherlands

2. Department of Neurology, Erasmus Medical Centre, Rotterdam, the Netherlands

3. Division of Pathology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands

Abstract

Despite the availability of vaccines, influenza virus infections continue to cause substantial morbidity and mortality in humans. Currently available influenza vaccines take primarily the hemagglutinin (HA) into account, but the highly variable nature of this protein as a result of antigenic drift has led to a recurrent decline in vaccine effectiveness.

Funder

HHS | Biomedical Advanced Research and Development Authority

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01959-21

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