The Conserved Translation Factor LepA Is Required for Optimal Synthesis of a Porin Family in Mycobacterium smegmatis-Reference-Cited by-同舟云学术

The Conserved Translation Factor LepA Is Required for Optimal Synthesis of a Porin Family in Mycobacterium smegmatis

Published:2021-02-22 Issue:6 Volume:203 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Fishbein Skye R. S.¹^ORCID,Tomasi Francesca G.¹,Wolf Ian D.¹,Dulberger Charles L.¹,Wang Albert¹,Keshishian Hasmik²,Wallace Luke²,Carr Steven A.²,Ioerger Thomas R.³,Rego E. Hesper⁴^ORCID,Rubin Eric J.¹

Affiliation:

1. Department of Immunology and Infectious Disease, Harvard TH Chan School of Public Health, Boston, Massachusetts, USA

2. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

3. Department of Computer Science and Engineering, Texas A&M University, College Station, Texas, USA

4. Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA

Abstract

The mycobacterial cell wall is a promising target for new antibiotics due to the abundance of important membrane-associated proteins. Defining mechanisms of synthesis of the membrane proteome will be critical to uncovering and validating drug targets.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.00604-20

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