Genetic Environment of the bla KPC-2 Gene in a Klebsiella pneumoniae Isolate That May Have Been Imported to Russia from Southeast Asia-Reference-Cited by-同舟云学术

Genetic Environment of the bla KPC-2 Gene in a Klebsiella pneumoniae Isolate That May Have Been Imported to Russia from Southeast Asia

Published:2017-02 Issue:2 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ageevets Vladimir¹,Sopova Julia²³,Lazareva Irina¹,Malakhova Maya⁴,Ilina Elena⁴,Kostryukova Elena⁴,Babenko Vladislav⁴^ORCID,Carattoli Alessandra⁵,Lobzin Yuri¹⁶,Uskov Alexander¹,Sidorenko Sergey¹⁶^ORCID

Affiliation:

1. Scientific Research Institute of Children's Infections, Saint Petersburg, Russia

2. Saint Petersburg Branch of Vavilov Institute of General Genetics, Saint Petersburg, Russia

3. Saint Petersburg State University, Saint Petersburg, Russia

4. Research Institute for Physical-Chemical Medicine, Moscow, Russia

5. Istituto Superiore di Sanità, Rome, Italy

6. North-Western State Medical University named after I. I. Mechnikov, Saint Petersburg, Russia

Abstract

ABSTRACT The nucleotide sequence of a bla KPC-2 -harboring plasmid (pKPCAPSS) from Klebsiella pneumoniae ST273 isolated in Saint Petersburg, Russia, from a patient with history of recent travel to Vietnam is presented. This 127,970-bp plasmid possessed both IncFII and IncR replicons. bla KPC-2 was localized on a hypothetical mobile element. This element was flanked by 38-bp inverted Tn 3 repeats and included a Tn 3 -specific transposase gene, macrolide resistance operon ( mphA-mrx-mphR ), and a fragment of bla TEM with unique polymorphisms.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01856-16

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