Analysis of Effector and Immunity Proteins of the GA2 Type VI Secretion Systems of Gut Bacteroidales-Reference-Cited by-同舟云学术

Analysis of Effector and Immunity Proteins of the GA2 Type VI Secretion Systems of Gut Bacteroidales

Published:2022-07-19 Issue:7 Volume:204 Page:
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Bao Hongxia¹²,Coyne Michael J.²³,García-Bayona Leonor²³,Comstock Laurie E.²³

Affiliation:

1. Genomics Research Center, College of Pharmacy, Harbin Medical University, Harbin, China

2. Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

3. Department of Microbiology, Duchossois Family Institute, University of Chicago, Chicago, Illinois, USA

Abstract

Humans are colonized with many gut Bacteroidales species at high density, allowing for extensive opportunities for contact-dependent antagonism. To begin to understand the antagonistic potential of the GA2 T6SSs of the gut Bacteroidales, we performed bioinformatic and experimental analyses of the three divergent regions containing the toxin effector and immunity genes.

Funder

Natural Science Foundation of Heilongjiang Province

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jb.00122-22

Reference36 articles.

1. Bacterial antagonism in host-associated microbial communities

2. Type VI secretion systems of human gut Bacteroidales segregate into three genetic architectures, two of which are contained on mobile genetic elements

3. Bacteroides fragilistype VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species

4. Human symbionts inject and neutralize antibacterial toxins to persist in the gut

5. Strain competition restricts colonization of an enteric pathogen and prevents colitis

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