Physiological Role of Acyl Coenzyme A Synthetase Homologs in Lipid Metabolism in Neurospora crassa-Reference-Cited by-同舟云学术

Physiological Role of Acyl Coenzyme A Synthetase Homologs in Lipid Metabolism in Neurospora crassa

Published:2013-09 Issue:9 Volume:12 Page:1244-1257
ISSN:1535-9778
Container-title:Eukaryotic Cell
language:en
Short-container-title:Eukaryot Cell

Author:

Roche Christine M.¹²,Blanch Harvey W.¹²,Clark Douglas S.¹²,Glass N. Louise²³

Affiliation:

1. Chemical and Biomolecular Engineering Department, The University of California, Berkeley, California, USA

2. Energy Biosciences Institute, The University of California, Berkeley, California, USA

3. Plant and Microbial Biology Department, The University of California, Berkeley, California, USA

Abstract

ABSTRACT Acyl coenzyme A (CoA) synthetase (ACS) enzymes catalyze the activation of free fatty acids (FAs) to CoA esters by a two-step thioesterification reaction. Activated FAs participate in a variety of anabolic and catabolic lipid metabolic pathways, including de novo complex lipid biosynthesis, FA β-oxidation, and lipid membrane remodeling. Analysis of the genome sequence of the filamentous fungus Neurospora crassa identified seven putative fatty ACSs (ACS-1 through ACS-7). ACS-3 was found to be the major activator for exogenous FAs for anabolic lipid metabolic pathways, and consistent with this finding, ACS-3 localized to the endoplasmic reticulum, plasma membrane, and septa. Double-mutant analyses confirmed partial functional redundancy of ACS-2 and ACS-3. ACS-5 was determined to function in siderophore biosynthesis, indicating alternative functions for ACS enzymes in addition to fatty acid metabolism. The N. crassa ACSs involved in activation of FAs for catabolism were not specifically defined, presumably due to functional redundancy of several of ACSs for catabolism of exogenous FAs.

Publisher

American Society for Microbiology

Subject

Molecular Biology,General Medicine,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/EC.00079-13

Reference69 articles.

1. Lipid metabolism in fungi;Chopra A;Crit. Rev. Microbiol.,1984

2. Mitochondrial fatty acid synthesis type II: more than just fatty acids;Hiltunen JK;J. Biol. Chem.,2009

3. Synthesis, storage and degradation of neutral lipids in yeast. BBA;Czabany T;Molecular and cell biology of lipids,2007

4. Enzymes of triacylglycerol synthesis and their regulation;Coleman RA;Prog. Lipid Res.,2004

5. Phospholipid synthesis and lipid composition of subcellular membranes in the unicellular eukaryote Saccharomyces cerevisiae

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A transcriptome profile of Wickerhamomyces anomalus incubated with chitosan revealed dynamic changes in gene expression and metabolic pathways;International Journal of Biological Macromolecules;2024-02

2. Enzymatic Strategies for the Biosynthesis of N‐Acyl Amino Acid Amides;ChemBioChem;2024-01-05

3. Oxidative Stress Induced by Lipotoxicity and Renal Hypoxia in Diabetic Kidney Disease and Possible Therapeutic Interventions: Targeting the Lipid Metabolism and Hypoxia;Antioxidants;2023-12-06

4. The Mechanism of Transcription Factor Swi6 in Regulating Growth and Pathogenicity of Ceratocystis fimbriata: Insights from Non-Targeted Metabolomics;Microorganisms;2023-10-30

5. Regulation of nutrient utilization in filamentous fungi;Applied Microbiology and Biotechnology;2023-08-04