LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response-Reference-Cited by-同舟云学术

LONP1 Is Required for Maturation of a Subset of Mitochondrial Proteins, and Its Loss Elicits an Integrated Stress Response

Published:2018-10-15 Issue:20 Volume:38 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Zurita Rendón Olga¹²,Shoubridge Eric A.¹²

Affiliation:

1. Montreal Neurological Institute, McGill University, Montreal, QC, Canada

2. Department of Human Genetics, McGill University, Montreal, QC, Canada

Abstract

LONP1, an AAA+ mitochondrial protease, is implicated in protein quality control, but its precise role in this process remains poorly understood. In this study, we have investigated the role of human LONP1 in mitochondrial proteostasis and gene expression.

Funder

Consejo Nacional de Ciencia y Tecnología

Gouvernement du Canada | Canadian Institutes of Health Research

Fonds de Recherche du Québec-Nature et Technologies

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00412-17

Reference41 articles.

1. The m-AAA Protease Defective in Hereditary Spastic Paraplegia Controls Ribosome Assembly in Mitochondria