Antimicrobial Susceptibility of Neisseria gonorrhoeae Isolated in Bangladesh (1997 to 1999): Rapid Shift to Fluoroquinolone Resistance

Author:

Rahman Motiur1,Sultan Zafar1,Monira Shirajum1,Alam Ashraful2,Nessa Khairun1,Islam Sonia3,Nahar Shamsun1,Shama-A-Waris 1,Alam Khan Shahnewaz4,Bogaerts Jozef1,Islam Nazrul3,Albert John1

Affiliation:

1. International Center for Diarrheal Disease Research, Bangladesh

2. M. A. G. Osmani Medical College, Sylhet, Bangladesh

3. Bangabandhu Sheikh Mujib Medical University, Shahbag

4. Concern Bangladesh, Dhaka

Abstract

ABSTRACT Periodic monitoring of antimicrobial susceptibility of Neisseria gonorrhoeae is essential for early detection of emergence of drug resistance. A total of 343 gonococcal strains isolated from high-risk and general populations in Bangladesh from 1997 to 1999 were studied. The MICs of penicillin, tetracycline, ciprofloxacin, ceftriaxone, and spectinomycin for the isolates were determined by the agar dilution method. Of the isolates from 1997, 9% were resistant (MIC ≥ 1.0 μg/ml) to ciprofloxacin, while 41 and 49% of the isolates from 1998 and 1999, respectively, were resistant to ciprofloxacin. Of the N. gonorrhoeae isolates from 1998 and 1999, 1.2 and 3.6%, respectively, both were penicillinase producing and displayed plasmid-mediated tetracycline resistance.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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