Botulism Due to Clostridium baratii Type F Toxin

Author:

Harvey Sydney M.1,Sturgeon Joan1,Dassey David E.2

Affiliation:

1. Public Health Laboratory

2. Acute Communicable Disease Control Unit, County of Los Angeles Department of Health Services, Los Angeles, California

Abstract

ABSTRACT Botulism results from consumption of preformed toxin or in vivo toxin elaboration in wounds or intestine. Of U.S. food-borne botulism cases since 1950, the majority were due to toxin A, but a significant number of suspect cases were never confirmed by culture or toxin detection. We report here a possible case of food-borne botulism attributed to toxin F production by a Clostridium baratii organism isolated from food consumed by the patient. The isolation of a toxin-producing Clostridium species other than Clostridium botulinum from food and stool requires deviation from the usual laboratory protocols, which may account for the lack of complete laboratory confirmation of clinically diagnosed cases.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Reference13 articles.

1. Allen, S. D., C. L. Emery, and J. A. Siders. 1999. Clostridium, p. 654-671. In P. R. Murray, E. J. Barron, M. Q. Pfaller, F. C. Tenover, and R. H. Yolken (ed.), Manual of clinical microbiology. American Society for Microbiology, Washington, D.C.

2. Aureli, P., L. Fenicia, B. Pasolini, M. Gianfranceschi, L. M. McCroskey, and C. L. Hatheway. 1986. Two cases of type E infant botulism caused by neurotoxigenic Clostridium butyricum in Italy. J. Infect. Dis.154:207-211.

3. Centers for Disease Control and Prevention. 1998. Botulism in the United States 1899-1996: handbook for epidemiologists clinicians and laboratory workers. Centers for Disease Control and Prevention Atlanta Ga.

4. Doyle M. P. 1989. Foodborne bacterial pathogens p. 147. Marcel Dekker Inc. New York N.Y.

5. East, A. K., P. T. Richardson, D. Allaway, M. D. Collins, T. A. Roberts, and D. E. Thompson. 1992. Sequence of the gene encoding type F neurotoxin of Clostridium botulinum.FEMS Microbiol. Lett.96:225-230.

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