Discrimination between Cases of Duodenal Ulcer and Gastritis on the Basis of Putative Virulence Factors of Helicobacter pylori

Author:

Yamaoka Yoshio1,Souchek Julianne2,Odenbreit Stefan3,Haas Rainer3,Arnqvist Anna45,Borén Thomas5,Kodama Tadashi6,Osato Michael S.1,Gutierrez Oscar7,Kim Jong G.8,Graham David Y.1

Affiliation:

1. Department of Medicine

2. Department of Health Services Research, Baylor College of MedicineVeterans Affairs Medical Center, Houston, Texas;

3. Max Von Pettenkofer-Institut, München, Germany

4. Division of Oral Microbiology, Department of Odontology

5. Department of Molecular Biology, Umeå University, Umeå, Sweden

6. Third Department of Internal Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan

7. Universidad Nacional de Colombia, Bogota, Colombia

8. Guro Hospital, Korea University College of Medicine, Seoul, Korea

Abstract

ABSTRACT The BabA, cagA , and vacA statuses of 827 Helicobacter pylori isolates were used in logistic regression models to discriminate duodenal ulcer from gastritis. Only BabA was a candidate for a universal virulence factor, but the low c statistic value (0.581) indicates that none of these factors were helpful in predicting the clinical presentation.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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