Organoselenium Has a Potent Fungicidal Effect on Cryptococcus neoformans and Inhibits the Virulence Factors-Reference-Cited by-同舟云学术

Organoselenium Has a Potent Fungicidal Effect on Cryptococcus neoformans and Inhibits the Virulence Factors

Published:2023-02-23 Issue: Volume: Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

De Jesus Daniel Felipe Freitas¹,De Freitas Aline Luiza Duarte¹,De Oliveira Isadora Maria²,De Almeida Larissa Costa¹,Bastos Rafael Wesley³,Spadari Cristina de Castro¹,Melo Analy Sales de Azevedo⁴,Santos Daniel de Assis⁵,Costa-Lotufo Letícia Veras¹^ORCID,Reis Flavia C. G.⁶⁷,Rodrigues Marcio L.⁶⁸,Stefani Hélio Alexandre²,Ishida Kelly¹^ORCID

Affiliation:

1. Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil

2. School of Pharmaceutical Sciences, University of São Paulo (USP), São Paulo, Brazil

3. Center of Biosciences, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil

4. Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil

5. Institute of Biomedical Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil

6. Carlos Chagas Institute, Oswaldo Cruz Foundation, Curitiba, Brazil

7. Center for Technological Development in Health (CDTS), Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

8. Institute of Microbiology Paulo de Góes, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil

Abstract

Cryptococcosis therapy is often limited by toxicity problems, antifungal tolerance, and high costs. Studies approaching chalcogen compounds, especially those containing selenium, have shown promising antifungal activity against pathogenic species.

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00759-22

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