Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis-Reference-Cited by-同舟云学术

Antiplasmodial Activity of Aryltetralone Lignans from Holostylis reniformis

Published:2007-07 Issue:7 Volume:51 Page:2346-2350
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

de Andrade-Neto Valter F.¹²,da Silva Tito³,Lopes Lucia M. Xavier³,do Rosário Virgílio E.⁴,de Pilla Varotti Fernando¹,Krettli Antoniana U.¹

Affiliation:

1. Laboratório de Malaria, Centro de Pesquisas René Rachou/FIOCRUZ, 30190-002, Belo Horizonte, MG, Brazil

2. Departamento de Parasitologia, Universidade Federal de Minas Gerais, UFMG, Av. Augusto de Lima, 1715, 30190-002, Belo Horizonte, MG, Brazil

3. Instituto de Química, Universidade Estadual Paulista, UNESP, C. P. 355, 14801-970, Araraquara, SP, Brazil

4. Instituto de Higiene e Medicina Tropical, Centro de Malaria e Doenças Tropicais, Universidade Nova de Lisboa, UNL, 1349-008, Lisboa, Portugal

Abstract

ABSTRACT Extracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum . The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7′ R ,8 S ,8′ S )-3′,4′-methylenedioxy-4,5-dimethoxy-2,7′-cyclolignan-7-one, were isolated and tested in vitro against P. falciparum. The three most active lignans showed 50% inhibitor concentrations of ≤0.32 μM. An evaluation of minimum lethal dose (30%) values showed low toxicity for these lignans in a hepatic cell line (Hep G2A16). Therefore, these compounds are potential candidates for the development of antimalarial drugs.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01344-06

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