Berberine derivatives as antileishmanial drugs-Reference-Cited by-同舟云学术

Berberine derivatives as antileishmanial drugs

Published:1990-05 Issue:5 Volume:34 Page:918-921
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Vennerstrom J L¹,Lovelace J K¹,Waits V B¹,Hanson W L¹,Klayman D L¹

Affiliation:

1. Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, D.C. 20307.

Abstract

Berberine, a quaternary alkaloid, and several of its derivatives were tested for efficacy against Leishmania donovani and Leishmania braziliensis panamensis in golden hamsters. Tetrahydroberberine was less toxic and more potent than berberine against L. donovani but was not as potent as meglumine antimonate (Glucantime), a standard drug for the treatment of leishmaniasis. Only berberine and 8-cyanodihydroberberine showed significant activity (greater than 50% suppression of lesion size) against L. braziliensis panamensis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.34.5.918

Reference15 articles.

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