Case-Control Study ComparingDe Novoand Daptomycin-Exposed Daptomycin-Nonsusceptible Enterococcus Infections

Abstract

ABSTRACTUnderstanding factors associated withde novodaptomycin-nonsusceptibleEnterococcus(DNSE) infections will aid in better understanding the mechanisms of daptomycin nonsusceptibility. We conducted a case-control study to compare patients with DNSE infections who were daptomycin treatment naïve (n= 9) and those with DNSE infections who had exposure to daptomycin (n= 13). Less frequent exposure to antimicrobials, increased susceptibility to nitrofurantoin and gentamicin, and shorter duration of hospitalization were associated withde novoDNSE infection, suggesting a potential community reservoir.