COVID-19 Vaccine Candidates Based on Modified Vaccinia Virus Ankara Expressing the SARS-CoV-2 Spike Protein Induce Robust T- and B-Cell Immune Responses and Full Efficacy in Mice-Reference-Cited by-同舟云学术

COVID-19 Vaccine Candidates Based on Modified Vaccinia Virus Ankara Expressing the SARS-CoV-2 Spike Protein Induce Robust T- and B-Cell Immune Responses and Full Efficacy in Mice

Published:2021-03-10 Issue:7 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

García-Arriaza Juan¹^ORCID,Garaigorta Urtzi¹,Pérez Patricia¹,Lázaro-Frías Adrián¹,Zamora Carmen¹,Gastaminza Pablo¹,del Fresno Carlos²,Casasnovas José M.³,S. Sorzano Carlos Óscar⁴,Sancho David²,Esteban Mariano¹

Affiliation:

1. Department of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

2. Laboratory of Immunobiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

3. Department of Macromolecular Structures, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

4. Biocomputing Unit, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain

Abstract

The continuous dissemination of the novel emerging SARS-CoV-2 virus, with more than 78 million infected cases worldwide and higher than 1,700,000 deaths as of 23 December 2020, highlights the urgent need for the development of novel vaccines against COVID-19. With this aim, we have developed novel vaccine candidates based on the poxvirus modified vaccinia virus Ankara (MVA) strain expressing the full-length SARS-CoV-2 spike (S) protein, and we have evaluated their immunogenicity in mice using DNA/MVA or MVA/MVA prime/boost immunization protocols.

Funder

Fondo Supera COVID-19

Ferrovial

MEC | Instituto de Salud Carlos III

MEC | Consejo Superior de Investigaciones Científicas

Fundación Mapfre

Fundación Banco Santander

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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