NADPH-Cytochrome P450 Reductase Ccr1 Is a Target of Tamoxifen and Participates in Its Antifungal Activity via Regulating Cell Wall Integrity in Fission Yeast-Reference-Cited by-同舟云学术

NADPH-Cytochrome P450 Reductase Ccr1 Is a Target of Tamoxifen and Participates in Its Antifungal Activity via Regulating Cell Wall Integrity in Fission Yeast

Published:2020-08-20 Issue:9 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Liu Qiannan¹,Guo Xiaoxu¹,Jiang Guanglie¹,Wu Guoxiang¹,Miao Hao¹,Liu Kun¹,Chen Si¹,Sakamoto Norihiro²,Kuno Takayoshi¹²,Yao Fan³,Fang Yue¹^ORCID

Affiliation:

1. Department of Microbial and Biochemical Pharmacy, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China

2. Division of Food and Drug Evaluation Science, Kobe University Graduate School of Medicine, Kobe, Japan

3. Department of Breast Surgery and Surgical Oncology, Research Unit of General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China

Abstract

Invasive fungal diseases are a leading cause of mortality among immunocompromised populations. Treatment is notoriously difficult due to the limited number of antifungal drugs as well as the emergence of drug resistance. Tamoxifen (TAM), a selective estrogen receptor modulator frequently used for the treatment of breast cancer, has been found to have antifungal activities and may be a useful addition to the agents used to treat fungal infectious diseases. However, the molecular mechanisms underlying its antifungal actions remain obscure.

Funder

National Natural Science Foundation of China

Doctoral Start-up Foundation of Liaoning Province

China Medical University

Natural Science Foundation of Liaoning Province

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00079-20

Reference34 articles.