Insights into the l , d -Transpeptidases and d , d -Carboxypeptidase of Mycobacterium abscessus: Ceftaroline, Imipenem, and Novel Diazabicyclooctane Inhibitors-Reference-Cited by-同舟云学术

Insights into the l , d -Transpeptidases and d , d -Carboxypeptidase of Mycobacterium abscessus: Ceftaroline, Imipenem, and Novel Diazabicyclooctane Inhibitors

Published:2020-07-22 Issue:8 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dousa Khalid M.¹^ORCID,Kurz Sebastian G.²,Taracila Magdalena A.³⁴,Bonfield Tracey⁴⁵,Bethel Christopher R.³,Barnes Melissa D.³⁴,Selvaraju Suresh⁶,Abdelhamed Ayman M.⁷,Kreiswirth Barry N.⁸,Boom W. Henry¹,Kasperbauer Shannon H.⁹,Daley Charles L.⁹,Bonomo Robert A.³⁴¹⁰¹¹¹²

Affiliation:

1. Division of Infectious Diseases & HIV Medicine, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA

2. Mount Sinai National Jewish Health Respiratory Institute, New York, New York, USA

3. Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA

4. Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

5. Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

6. Department of Microbiology, MetroHealth Medical Center, Cleveland, Ohio, USA

7. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

8. Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA

9. Division of Mycobacterial and Respiratory Infections, National Jewish Health, Denver, Colorado, USA

10. Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

11. Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

12. Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

Abstract

Mycobacterium abscessus is a highly drug-resistant nontuberculous mycobacterium (NTM). Efforts to discover new treatments for M. abscessus infections are accelerating, with a focus on cell wall synthesis proteins ( M. abscessus l , d -transpeptidases 1 to 5 [Ldt Mab1 to Ldt Mab5 ] and d , d -carboxypeptidase) that are targeted by β-lactam antibiotics.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

U.S. Department of Veterans Affairs

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00098-20

Reference18 articles.

1. Pulmonary Nontuberculous Mycobacterial Disease, Ontario, Canada, 1998–2010

2. Mycobacterium abscessus: a new antibiotic nightmare