Cross-Recognition of N -Formylmethionine Peptides Is a General Characteristic of H2-M3-Restricted CD8 + T Cells-Reference-Cited by-同舟云学术

Cross-Recognition of N -Formylmethionine Peptides Is a General Characteristic of H2-M3-Restricted CD8 + T Cells

Published:2005-07 Issue:7 Volume:73 Page:4423-4426
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Ploss Alexander¹²,Tran An¹,Menet Ewa¹,Leiner Ingrid¹,Pamer Eric G.¹

Affiliation:

1. Infectious Diseases Service, Department of Medicine and Laboratory of Antimicrobial Immunity, Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10021

2. Immunology Program, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021

Abstract

ABSTRACT H2-M3-restricted CD8 + T cells can exhibit cross-reactivity to different bacterially derived N -formylmethionine peptides. The extent of this promiscuity is unclear. We deleted the nonredundant fMIVTLF epitope and found that Listeria monocytogenes still primed fMIVTLF-specific T cells. Thus, cross-reactivity appears to be a more general characteristic of H2-M3-restricted T cells.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.7.4423-4426.2005

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