Genome Scale Identification of Treponema pallidum Antigens-Reference-Cited by-同舟云学术

Genome Scale Identification of Treponema pallidum Antigens

Published:2005-07 Issue:7 Volume:73 Page:4445-4450
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

McKevitt Matthew¹,Brinkman Mary Beth¹,McLoughlin Melanie²,Perez Carla¹,Howell Jerrilyn K.²,Weinstock George M.³,Norris Steven J.²⁴,Palzkill Timothy¹

Affiliation:

1. Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030

2. Department of Pathology and Laboratory Medicine

3. Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas

4. Department of Microbiology and Molecular Genetics, University of Texas—Houston Medical School, 6431 Fannin Street, Houston, Texas 77030

Abstract

ABSTRACT Antibody responses for 882 of the 1,039 proteins in the proteome of Treponema pallidum were examined. Sera collected from infected rabbits were used to systematically identify 106 antigenic proteins, including 22 previously identified antigens and 84 novel antigens. Additionally, sera collected from rabbits throughout the course of infection demonstrated a progression in the breadth and intensity of humoral immunoreactivity against a representative panel of T. pallidum antigens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.73.7.4445-4450.2005

Reference35 articles.

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5. Identification of a Treponema pallidum Laminin-Binding Protein

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