Synergy of levofloxacin (L-ofloxacin) and oxacillin against quinolone-resistant Staphylococcus aureus, measured by the time-kill method-Reference-Cited by-同舟云学术

Synergy of levofloxacin (L-ofloxacin) and oxacillin against quinolone-resistant Staphylococcus aureus, measured by the time-kill method

Published:1993-02 Issue:2 Volume:37 Page:339-341
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Patel J A¹,Pachucki C T¹,Lentino J R¹

Affiliation:

1. Medical Service, Edward Hines, Jr., Veterans Affairs Hospital, Hines, Illinois 60141.

Abstract

The synergistic activity of levofloxacin and oxacillin against levofloxacin-resistant isolates of methicillin-resistant Staphylococcus aureus was tested by the time-kill method. The combination of levofloxacin at 1/4 the MIC for the isolate plus oxacillin at 8 micrograms/ml (< 1/4 the MIC) was synergistic against seven of nine isolates at 8 h, although no significant synergy was demonstrated at 24 h. This combination may prove to be effective against multidrug-resistant methicillin-resistant S. aureus, and further studies are warranted.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.37.2.339

Reference17 articles.

1. Antimicrobial activity evaluations of two new quinolones, PD 127391 (CI-960 and AM-1091) and PD 131628;Barret M. S.;Diagn. Microbiol. Infect. Dis.,1991

2. Antibiotic susceptibility testing by a standardized single disk method;Bauer A. W.;Am. J. Clin. Pathol.,1966

3. Vergleich der antibakterillen Profile von Ciprofloxacin, Norfloxacin, Pefloxacin, Ofloxacin, Enoxacin, Pipemidesaure and Nalidixinasaure;Bauernfeind A.;Fortschr. Antimikrob. Antineoplast. Chemother.,1984

4. Rapid development of ciprofloxacin resistance in methicillin-susceptible and -resistant Staphylococcus aureus;Blumberg H. M.;J. Infect. Dis.,1991

5. Combination of ofloxacin and other antimicrobial agents;Chin N. X.;J. Chemother.,1990

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The pharmacokinetic interaction between levofloxacin and sunitinib;Pharmacological Reports;2015-06

2. Levofloxacin Disposition in Cerebrospinal Fluid in Patients with External Ventriculostomy;Antimicrobial Agents and Chemotherapy;2003-10

3. Cerebrospinal Fluid Penetration of Levofloxacin in Patients with Spontaneous Acute Bacterial Meningitis;Clinical Infectious Diseases;2001-11

4. Comparative evaluation of oral levofloxacin and parenteral nafcillin in the treatment of experimental methicillin-susceptible Staphylococcus aureus osteomyelitis in rabbits;Journal of Antimicrobial Chemotherapy;2001-08-01

5. Levofloxacin, a Second‐Generation Fluoroquinolone;Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy;1998-09-10