Affiliation:
1. NHC Key Laboratory of Medical Virology and Viral Diseases (National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention), WHO WPRO Regional Reference Measles/Rubella Laboratory, Beijing, People’s Republic of China
Abstract
Varicella, also known as chickenpox, is a highly contagious disease, caused by varicella-zoster virus (VZV). Varicella is a common childhood disease that can be prevented by a live attenuated vaccine. The first available vaccine was derived from the parental Oka strain in Japan in 1974. Several live attenuated vaccines based on the Oka strain are currently available worldwide. Among the four vaccines produced in China, the vaccine manufactured by Changchun BCHT Biotechnology, also known as Baike, has been reported to be very efficacious. Comparative genomic analysis of the Baike vaccine with other Oka vaccine strains identified sites that might be involved in vaccine efficacy, as well as important for the biology of the virus.
Funder
National Key Research and Development Program
Key Technologies R&D Program of the National Ministry of Science
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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