Affiliation:
1. Department of Chemistry, Department of Biochemistry and Molecular Biology, and Lombardi Cancer Center, Georgetown University, Washington DC 20057
Abstract
ABSTRACT
We report on the development of a new SYBR Green I-based plate assay for analyzing the activities of antimalarial drugs against intraerythrocytic
Plasmodium falciparum
. This assay is considerably faster, less labor-intensive, and less expensive than conventional radiotracer (e.g., [
3
H]hypoxanthine and [
3
H]ethanolamine)-based assays or
P. falciparum
lactate dehydrogenase activity-based assays. The assay significantly improves the pace at which antimalarial drug discovery efforts may proceed.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Cited by
232 articles.
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