Affiliation:
1. Research and Development, Valeant Pharmaceuticals International, Costa Mesa, California 92626
Abstract
ABSTRACT
The disposition and metabolic profiles of [
14
C]viramidine and [
14
C]ribavirin were compared in rat and monkey red blood cells and liver. Our data reveal that the total ribavirin-related components (ribavirin plus its mono-, di-, and triphosphate metabolites) may account for most of the drug in monkey liver following prolonged oral administration of viramidine.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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