Affiliation:
1. Department of Microbiology and Chemotherapy, Nippon Roche Research Center, Kajiwara, Kamakura-247, Japan
Abstract
Of some 350 microorganisms screened, four strains of
Pithomyces
species were found to carry out regio-selective hydroxylation of patchoulol, a sesquiterpene, to 10-hydroxypatchoulol:
Pithomyces
sp. NRJ201,
P. chartarum
NRJ210, and, to a lesser extent,
P. cynodontis
ATCC 26150 and
P. atro-olivaceus
IFO 6651 were found to catalyze this reaction. A method has been developed by which 10-hydroxypatchoulol was obtained in 25 to 45% yields in 1- to 5-liter fermentation jars at 2 to 4 g of patchoulol per liter and isolated as pure material in 30% yields.
Publisher
American Society for Microbiology
Subject
Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology
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