Affiliation:
1. New York University Medical Center, Skirball Institute, New York, New York 10016
Abstract
ABSTRACT
Glycerol monolaurate (GML) inhibits the expression of virulence factors in
Staphylococus aureus
and the induction of vancomycin resistance in
Enterococcus faecalis
, presumably by blocking signal transduction. Although GML is rapidly hydrolyzed by bacteria, one of the products, lauric acid, has identical inhibitory activity and is metabolized much more slowly. At least four distinct GML-hydrolyzing activities are identified in
S. aureus
: the secreted Geh lipase, residual supernatant activity in a
geh
-null mutant strain, a novel membrane-bound esterase, and a cytoplasmic activity.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
79 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献