Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo-Reference-Cited by-同舟云学术

Violacein Extracted from Chromobacterium violaceum Inhibits Plasmodium Growth In Vitro and In Vivo

Published:2009-05 Issue:5 Volume:53 Page:2149-2152
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Lopes Stefanie C. P.¹²,Blanco Yara C.¹²,Justo Giselle Z.³,Nogueira Paulo A.⁴,Rodrigues Francisco L. S.⁴,Goelnitz Uta⁵,Wunderlich Gerhard⁵,Facchini Gustavo⁶,Brocchi Marcelo¹,Duran Nelson⁷,Costa Fabio T. M.¹²

Affiliation:

1. Departamento de Microbiologia e Imunologia, Instituto de Biologia, IB, Universidade Estadual de Campinas, UNICAMP, P.O. Box 6109, 13083-970 Campinas, SP, Brazil

2. Departamento de Parasitologia, IB, UNICAMP, P.O. Box 6109, 13083-970 Campinas, SP, Brazil

3. Departamento de Bioquímica, Universidade Federal de São Paulo, UNIFESP, Rua 3 de Maio 100, 04044-020 São Paulo, SP, Brazil

4. IPEPATRO/CEPEM, BR 364, KM 4.5, 78900-970 Porto Velho, RO, Brazil

5. Departamento de Parasitologia, ICB-2, Universidade de São Paulo, USP, São Paulo, SP, Brazil

6. Departamento de Fisiologia e Biofísica, IB, UNICAMP, P.O. Box 6109, 13083-970 Campinas, SP, Brazil

7. Instituto de Química, Laboratório de Química Biológica, IQ, UNICAMP, C.P. 6154, 13083-970 Campinas, SP, Brazil

Abstract

ABSTRACT Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum . It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi -infected mice from a lethal challenge.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00693-08

Reference16 articles.

1. de Carvalho, D. D., F. T. M. Costa, N. Duran, and M. Haun. 2006. Cytotoxic activity of violacein in human colon cancer cells. Toxicol. In Vitro20:1514-1521.

2. di Santi, S. M., M. Boulos, M. A. Vasconcelos, S. Oliveira, A. Couto, and V. E. Rosário. 1987. Characterization of Plasmodium falciparum strains of the State of Rondonia, Brazil, using microtests of sensitivity to antimalarials, enzyme typing and monoclonal antibodies. Rev. Inst. Med. Trop. Sao Paulo29:142-147.

3. Durán, N., V. Campos, R. Riveros, A. Joyas, M. F. Pereira, and M. Haun. 1989. Bacterial chemistry. III. Preliminary studies on trypanosomal activities of Chromobacterium violaceum products. An. Acad. Bras. Cienc.61:31-36.

4. Durán, N., and C. F. Menck. 2001. Chromobacterium violaceum: a review of pharmacological and industrial perspectives. Crit. Rev. Microbiol.27:201-222.

5. Durán, N., G. Z. Justo, C. V. Ferreira, P. S. Melo, L. Cordi, and D. Martins. 2007. Violacein: properties and biological activities. Biotechnol. Appl. Biochem.48:127-133.

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