Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus-Reference-Cited by-同舟云学术

Isolation and characterization of phosphonoacetic acid-resistant mutants of human cytomegalovirus

Published:1987-04 Issue:4 Volume:61 Page:1291-1295
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

D'Aquila R T,Summers W C

Abstract

Mutants of the human cytomegalovirus (HCMV) that were 6- to 13-fold more resistant to phosphonoacetic acid than the wild-type HCMV (Towne) were isolated. Extracts from mycoplasma-free, mutant-infected cells had phosphonoacetate-resistant DNA polymerase activity in vitro. This strongly suggests that the selected mutations are in the HCMV DNA polymerase genes of these viruses.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.61.4.1291-1295.1987

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