Affiliation:
1. Trudeau Institute, Inc., Saranac Lake, New York 12983.
Abstract
Severe combined immunodeficiency (SCID) mice resolve naturally acquired Pneumocystis carinii pneumonia after reconstitution with immunocompetent spleen cells and can therefore be used as a model to study latent P. carinii infection. Neither P. carinii nor amplified P. carinii DNA was detected in the lungs of SCID mice killed 21 days after spleen cell reconstitution. Furthermore, SCID mice that recovered from P. carinii infection failed to reactivate the infection after they were either depleted of CD4+ cells for up to 84 days or depleted of CD4+ cells and treated with corticosteroid for 35 days. These results indicate that an immune response to P. carinii can completely clear the organism from the host. This supports the hypothesis that P. carinii pneumonia that develops in immunocompromised patients may be a new infection resulting from exposure to an exogenous source of P. carinii and not necessarily from reactivation of latent infection.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference24 articles.
1. Pneumocystis carinii, an opportunist in immunocompromised patients;Bartlett M. S.;Clin. Microbiol. Rev.,1991
2. Inflammatory responses to Pneumocystis carinii in mice selectively depleted of helper T;Beck J. M.;Iymphocytes. Am. J. Respir. Cell Mol. Biol.,1991
3. Correlation of morphologic diagnosis of Pneumocystis carinii with the presence of Pneumocystis DNA amplified by the polymerase chain reaction;Blumenfeld W.;Mod. Pathol.,1992
4. Resistance to Pneumocystis carinii (PC) infection in mice that recovered from PC infection and deprived of CD4+ cells;Chen W.;J. Immunol.,1993
5. Extrapulmonary Pneumocystis carinii infections in the acquired immunodeficiency syndrome;Cohen 0.;Arch. Intern. Med.,1991
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