Statins as Potential Antimalarial Drugs: Low Relative Potency and Lack of Synergy with Conventional Antimalarial Drugs-Reference-Cited by-同舟云学术

Statins as Potential Antimalarial Drugs: Low Relative Potency and Lack of Synergy with Conventional Antimalarial Drugs

Published:2009-05 Issue:5 Volume:53 Page:2212-2214
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Wong Rina P. M.¹,Davis Timothy M. E.¹

Affiliation:

1. School of Medicine and Pharmacology, University of Western Australia, Nedlands, Western Australia, Australia

Abstract

ABSTRACT The in vitro sensitivity of Plasmodium falciparum to atorvastatin and rosuvastatin was assessed using chloroquine-sensitive and chloroquine-resistant strains. Although atorvastatin was more potent, it had weak activity (mean 50% inhibitory concentration of ≥17 μM) and an indifferent interaction with chloroquine and dihydroartemisinin. Bioassay of plasma from an atorvastatin-treated subject showed similar results.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01469-08

Reference29 articles.

1. Andersson, M., P. Low, and M. Bakhiet. 1996. Lovastatin inhibits interferon-gamma-induced Trypanosoma brucei brucei proliferation: evidence for mevalonate pathway involvement. J. Interferon Cytokine Res.16:435-439.

2. Berenbaum, M. C. 1978. A method for testing for synergy with any number of agents. J. Infect. Dis.137:122-130.

3. Statins Alone Are Ineffective in Cerebral Malaria but Potentiate Artesunate

4. Borek-Dohalsky, V., J. Huclova, B. Barrett, B. Nemec, I. Ulc, and I. Jelinek. 2006. Validated HPLC-MS-MS method for simultaneous determination of atorvastatin and 2-hydroxyatorvastatin in human plasma-pharmacokinetic study. Anal. Bioanal. Chem.386:275-285.

5. Butcher, G. A., and R. E. Sinden. 2003. Persistence of atovaquone in human sera following treatment: inhibition of Plasmodium falciparum development in vivo and in vitro. Am. J. Trop. Med. Hyg.68:111-114.

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Neutrophil Extracellular Traps: A Crucial Factor in Post-Surgical Abdominal Adhesion Formation;Cells;2024-06-06

2. Antiplasmodial, Trypanocidal, and Genotoxicity In Vitro Assessment of New Hybrid α,α-Difluorophenylacetamide-statin Derivatives;Pharmaceuticals;2023-05-24

3. Continuous Wavelet Transform for Simultaneous Determination of Atorvastatin and Rosuvastatin in Combined Pharmaceutical Formulations;Journal of Applied Spectroscopy;2022-01

4. An integrated virtual screening and drug repurposing strategy for the discovery of new antimalarial drugs against Plasmodium falciparum phosphatidylinositol 3‐kinase;Journal of Cellular Biochemistry;2021-05-17

5. A Fast and Validated Reversed-Phase HPLC Method for Simultaneous Determination of Simvastatin, Atorvastatin, Telmisartan and Irbesartan in Bulk Drugs and Tablet Formulations;Scientia Pharmaceutica;2017-12-19