Efficient Inhibition of Hepatitis B Virus (HBV) Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors during Infection-Reference-Cited by-同舟云学术

Efficient Inhibition of Hepatitis B Virus (HBV) Replication and cccDNA Formation by HBV Ribonuclease H Inhibitors during Infection

Published:2021-11-17 Issue:12 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Chauhan Ranjit¹,Li Qilan¹²,Woodson Molly E.¹²,Gasonoo Makafui²³,Meyers Marvin J.²³,Tavis John E.¹²⁴^ORCID

Affiliation:

1. Department of Molecular Microbiology and Immunology, School of Medicine, Saint Louis University, Saint Louis, Missouri, USA

2. Saint Louis University Institute for Drug and Biotherapeutic Innovation, Saint Louis, Missouri, USA

3. Department of Chemistry, Saint Louis University, Saint Louis, Missouri, USA

4. Saint Louis University Liver Center, Saint Louis, Missouri, USA

Abstract

The Hepatitis B virus (HBV) ribonuclease H (RNase H) is an attractive but unexploited drug target. Here, we addressed three limitations to the current state of RNase H inhibitor development: (a) Efficacy has been assessed only in transfected cell lines. (b) Cytotoxicity data are from transformed cell lines rather than primary cells. (c) It is unknown how the compounds work against nucleos(t)ide analog resistant HBV strains.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01460-21

Reference41 articles.

1. Seeger C, Zoulim F, Mason WS. 2013. Hepadnaviruses, p 2185–2221. In Knipe DM, Howley PM (ed), Fields Virology, 6th ed. Philadelphia: Lippincott Williams & Wilkins.

2. Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study

3. Hepatitis B virus infection

4. HBV replication inhibitors

5. Current treatment guidelines of chronic hepatitis B: The role of nucleos(t)ide analogues and peginterferon

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