Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans-Reference-Cited by-同舟云学术

Recombinant Paraprobiotics as a New Paradigm for Treating Gastrointestinal Nematode Parasites of Humans

Published:2021-02-17 Issue:3 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Li Hanchen¹,Abraham Ambily¹,Gazzola David¹,Hu Yan¹,Beamer Gillian²,Flanagan Kelly¹,Soto Ernesto¹,Rus Florentina¹,Mirza Zeynep¹,Draper Austin³,Vakalapudi Sridhar³,Stockman Cheryl⁴,Bain Perry⁴,Urban Joseph F.⁵,Ostroff Gary R.¹,Aroian Raffi V.¹^ORCID

Affiliation:

1. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA

2. Department of Infectious Disease and Global Health, Tufts University, North Grafton, Massachusetts, USA

3. Synthetic Biomanufacturing Facility, Utah State University, Logan, Utah, USA

4. Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA

5. United States Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Diet, Genomics, Immunology Laboratory, Beltsville, Maryland, USA

Abstract

Gastrointestinal nematodes (GINs) of humans, e.g., hookworms, negatively impact childhood growth, cognition, nutrition, educational attainment, income, productivity, and pregnancy. Hundreds of millions of people are targeted with mass drug administration (MDA) of donated benzimidazole anthelmintics.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

USDA | National Institute of Food and Agriculture

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01469-20

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1. Preventive Chemotherapy in the Fight against Soil-Transmitted Helminthiasis: Achievements and Limitations

2. Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm