Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to para -Aminosalicylic Acid in Mycobacterium tuberculosis-Reference-Cited by-同舟云学术

Decreased Methylenetetrahydrofolate Reductase Activity Leads to Increased Sensitivity to para -Aminosalicylic Acid in Mycobacterium tuberculosis

Published:2022-01-18 Issue:1 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Yu Ji-fang¹²^ORCID,Xu Jin-tian¹²^ORCID,Yang Shan-shan¹,Gao Mei-na³,Si Hao-rui¹²,Xiong Dong-yan¹²,Gu Jing¹,Wu Zhi-long⁴,Zhou Jie⁴,Deng Jiao-yu¹⁵^ORCID

Affiliation:

1. Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, People’s Republic of China

2. University of Chinese Academy of Sciences, Beijing, People’s Republic of China

3. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China

4. Foshan Fourth People's Hospital, Foshan, People’s Republic of China

5. Guangdong Province Key Laboratory of TB Systems Biology and Translational Medicine, Foshan Institude of Industrial Technology, Chinese Academic of Sciences, Foshan, People’s Republic of China

Abstract

Tuberculosis (TB), caused by Mycobacterium tuberculosis , is one of the most fatal diseases in the world. Methylenetetrahydrofolate reductase (MTHFR) catalyzes the production of 5-methyltetrahydrofolate (5-CH 3 -THF), which is required for the de novo biosynthesis of methionine in bacteria. Here, we identified Rv2172c as an MTHFR in M. tuberculosis through in vitro and in vivo analyses and determined that the protein is essential for the in vitro growth of the bacterium.

Funder

Strategic Priority Research Program of the Chinese Academy of Sciences

Guangdong Basic and Applied Basic Research Foundation

Foshan Science and Technology Innovation Project

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01465-21

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1. Treatment of Gonorrhoea with Single Oral Doses of Rifampicin