Affiliation:
1. Section of Infectious Diseases and Medical Oncology, Medical Service, Veterans Administration Hospital, Washington, D.C. 20422
Abstract
The entry of nafcillin into the cerebrospinal fluid (CSF) of humans was studied in the absence of meningeal inflammation. Twenty studies were performed in 18 patients receiving 40 mg of sodium nafcillin per kg intravenously over 30 min. The CSF specimens were obtained at 1, 2, 3, and 4 h postinfusion, and sera were obtained at 5 min and 1, 2, 3, and 4 h. Nafcillin was uniformly detected in the lumbar CSF at 1 h, peaked at 2 h postinfusion, and was still detectable in the CSF of three of four patients studied at 4 h.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference5 articles.
1. Benner J. E. and P. D. Hoeprich. 1972. Acute bacterial meningitis p. 932-942. In P. D. Hoeprich (ed.) Infectious diseases. Harper & Row Publishers Inc. Hagerstown Md.
2. Clinical evaluation of nafcillin in patients with severe staphylococcal disease;Eickhoff T. C.;N. Engl. J. Med.,1965
3. Grove D. C. and W. A. Randall. (ed.). 1955. Assay methods of antibiotics. A laboratory manual. Medical Encyclopedia Inc. New York.
4. Nafcillin treatment of Staphylococcus aureus meningitis;Ruiz D. E.;Antimicrob. Agents Chemother.,1976
5. Susceptibility of Staphylococcus aureus and Staphylococcus epidermidis to 65 antibiotics;Sabath L. D.;Antimicrob. Agents Chemother.,1976
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献