A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 Infection-Reference-Cited by-同舟云学术

A SCID Mouse Model To Evaluate the Efficacy of Antivirals against SARS-CoV-2 Infection

Published:2022-08-24 Issue:16 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Abdelnabi Rana¹,Foo Caroline S.¹,Kaptein Suzanne J. F.¹,Boudewijns Robbert¹,Vangeel Laura¹,De Jonghe Steven¹,Jochmans Dirk¹²³,Weynand Birgit⁴,Neyts Johan¹²³^ORCID

Affiliation:

1. KU Leuven Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium

2. The VirusBank, Leuven, Belgium

3. Global Virus Network, Baltimore, Maryland, USA

4. KU Leuven Department of Imaging and Pathology, Division of Translational Cell and Tissue Research, Leuven, Belgium

Abstract

Unlike the ancestral SARS-CoV-2 strain, the Beta (B.1.351) variant of concern has been reported to replicate to some extent in WT mice (C57BL/6 and BALB/c). We demonstrate here that infection of SCID mice with the Beta variant resulted in high viral loads in the lungs on day 3 postinfection.

Funder

Bill and Melinda Gates Foundation

EC | Horizon 2020 Framework Programme

Fonds Wetenschappelijk Onderzoek

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00758-22

Reference27 articles.

1. 15 million people have died in the pandemic, WHO says