Mixtures of Insect-Pathogenic Viruses in a Single Virion: towards the Development of Custom-Designed Insecticides

Author:

Beperet Inés1,Simón Oihane23ORCID,López-Ferber Miguel4,van Lent Jan5,Williams Trevor6ORCID,Caballero Primitivo123

Affiliation:

1. Departamento de Investigación y Desarrollo, Bioinsectis SL, Noain, Navarra, Spain

2. Institute for Multidisciplinary Research in Applied Biology, Universidad Pública de Navarra, Pamplona, Navarra, Spain

3. Departamento de Agronomía, Biotecnología y Alimentación, Universidad Pública de Navarra, Pamplona, Navarra, Spain

4. LGEI, Ecole des Mines d’Alès, Institut Mines-Télécom et Université de Montpellier Sud de France, Alès, France

5. Laboratory of Virology, Wageningen University and Research, Wageningen, The Netherlands

6. Instituto de Ecología AC (INECOL), Xalapa, Mexico

Abstract

Alphabaculoviruses are used as biological insecticides and expression vectors in biotechnology and medical applications. We demonstrate that in caterpillars infected with particular mixtures of viruses, the genomes of different baculovirus species can be enveloped together within individual virions and occluded within proteinaceous occlusion bodies.

Funder

Ministerio de Ciencia, Innovación y Universidades

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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