Integrated Pathophysiology of Pyelonephritis

Author:

Choong Ferdinand X.1,Antypas Haris1,Richter-Dahlfors Agneta1

Affiliation:

1. Swedish Medical Nanoscience Center, Department of Neuroscience, Karolinska Institutet, SE-171 77, Stockholm, Sweden

Abstract

ABSTRACT Pyelonephritis represents a subset of urinary tract infections that occur from bacteria ascending from the lower to the upper reaches of the genitourinary system, such as the kidney. The renal system contains a range of hydrodynamically and immunologically challenging, interconnected microenvironments where the invading pathogen may populate during the course of the infection. The situation at the infection foci changes dynamically, vacillating between bacterial colonization and clearance, to which the outcome is a summation of all host-pathogen elements in play. A selection of important determinants includes factors of microbial origin, effects of eukaryotic cell signaling, physiological facets of the infected organ, and signals from distal organs. Improved understanding of the multifactorial aspects of molecular pathogenesis of infection requires intravital, cross-disciplinary approaches with high spatio-temporal resolution. The advancement of such approaches promises to eventually provide a comprehensive understanding of the integrated pathophysiology of pyelonephritis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference116 articles.

1. Bostwick DG (ed). 1999. Uropathology . Urologic Clinics of North America vol 26(4):677–828. WB Saunders Co Philadelphia PA.

2. Vercellone A Stratta P. 1990. Tubulo-interstitial nephropathies p 197–205. In Amerio A Coratelli P Massry S (ed) Proceedings of the 4th Bari Seminar in Nephrology . Kluwer Academic Publishers Boston MA.

3. Ronald AR Nicolle LE . 2002. Infections of the upper urinary tract p 845–869. In Schrier RW (ed). Diseases of the Kidney and Urinary Tract 7th ed. Lippincott Williams & Wilkins Philadelphia PA.

4. Ifergan J Pommier R Brion MC Glas L Rocher L Bellin MF. 2012. Imaging in upper urinary tract infections. Diagn Interv Imaging 93: 509–519. [PubMed][CrossRef]

5. Eaton DC Pooler JD Vander AJ. 2009. Vander’s Renal Physiology 7th ed. McGraw-Hill Medical New York NY.

Cited by 6 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3