Affiliation:
1. Division of Infectious Diseases, Department of Medicine, University of British Columbia, Vancouver, BC V6H 3Z6, Canada
Abstract
ABSTRACT
Reversible protein phosphorylation is the most common type of epigenetic posttranslational modification in living cells used as a major regulation mechanism of biological processes. The
Mycobacterium tuberculosis
genome encodes for 11 serine/threonine protein kinases that are responsible for sensing environmental signals to coordinate a cellular response to ensure the pathogen’s infectivity, survival, and growth. To overcome killing mechanisms generated within the host during infection,
M. tuberculosis
enters a state of nonreplicating persistence that is characterized by arrested growth, limited metabolic activity, and phenotypic resistance to antimycobacterial drugs. In this article we focus our attention on the role of
M. tuberculosis
serine/threonine protein kinases in sensing the host environment to coordinate the bacilli’s physiology, including growth, cell wall components, and central metabolism, to establish a persistent infection.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology
Cited by
22 articles.
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